What are the types of antigens in the novel coronavirus antigen detection kit?

Definition of antigen:

It is a substance that can combine with TCR of T and BCR (lymphocyte antigen receptor) of B, promote their proliferation and differentiation, produce antibodies or sensitized cells, and combine with them to exert immune effects.

Two characteristics of antigen:


The ability of antigen to stimulate the body to produce immune response, induce antibodies or sensitize lymphocytes.

Able to stimulate response


Antigen has specific binding ability with the its induced antibody or sensitized lymphocyte

The product (antibody, etc.) after the stimulation reaction can specifically bind to itself

The classification guided by this: immunogen = complete antigen, incomplete antigen (only antigenicity) = hapten

Factors influencing immunogenicity

A.Contribution of the antigen

The following are all positively related


2.Chemical complexity

3.Chemical composition

4.Conformation and accessibility

5.Physical form

B.Contribution of the interaction between host and antigen


Specificity refers to the specificity that the antigen stimulates the body to produce an immune response and the reaction of its response products = a specific antigen can only stimulate the body to produce specific antibodies or sensitized lymphocytes, and can only specifically bind to the antibody or lymphocytes that respond to the antibody.

the types of epitope

conformational epitope& sequential epitope


Type of antigen:

TD Ag (thymus dependent antigen): this kind of antigen stimulates B to produce antibodies that depend on t help, also known as T cell dependent antigen. [most human proteins are]

Ti Ag (thymus independent antigen): this kind of antigen stimulates B to produce antibodies independent of t help, also known as T cell dependent antigen.

Compared with the two, TD AG is more versatile:

Nonspecific immunostimulators:

Not typical but awesome

Superantigens are generally:

Extracellular toxin, retroviral protein

TCR binding site V β \ beta β

Direct stimulation of T cells

The reactive cells were CD4 + T cells

MHC binding site: non polypeptide region


Also known as mitogen, it can cause cells to undergo mitosis and then proliferate.

It is an important mitogen that acts on T and B cells of human and mouse.

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